| Catalog# |
C229 |
| Source |
E.coli |
| Description |
Recombinant Human Geranylgeranyl Pyrophosphate Synthase/GGPS1 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Glu300) of Human GGPS1 fused with a His tag at the N-terminus. |
| Names |
Geranylgeranyl Pyrophosphate Synthase, GGPP Synthase, GGPPSase, (2E,6E)-Farnesyl Diphosphate Synthase, Dimethylallyltranstransferase, Farnesyl Diphosphate Synthase, Farnesyltranstransferase, Geranylgeranyl Diphosphate Synthase, Geranyltranstransferase, GG |
| Accession # |
O95749 |
| Formulation |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0 |
| Shipping |
The product is shipped on dry ice/ice packs. |
| Storage |
Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles. |
| Purity |
Greater than 95% as determined by reducing SDS-PAGE. |
| Endotoxin |
Less than 0.1 ng/μg (1 IEU/μg). |
| Amino Acid Sequence |
MGSSHHHHHHSSGLVPRGSHMEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDK LQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPD AVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKP LLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
|
| Background |
Geranylgeranyl pyrophosphate synthase (GGPS1) is a member of the FPP/GGPP synthase family. GGPS1 is highly expressed in testis, heart and skeletal muscle. GGPS1 is localized in the cytoplasm and has geranylgeranyl diphosphate (GGPP) synthase activity. It catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. Other transcriptional splice variants have been found. |
