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C628
Recombinant Human Proteinase 3/Myeloblastin/PRTN3
10ug
840
756
现货
国产
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C628
Recombinant Human Proteinase 3/Myeloblastin/PRTN3
50ug
2520
2268
现货
国产
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C628
Recombinant Human Proteinase 3/Myeloblastin/PRTN3
500ug
12320
11088
现货
国产
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C628
Recombinant Human Proteinase 3/Myeloblastin/PRTN3
1mg
17600
15840
现货
国产
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Catalog# C628 Source HEK293 Description Recombinant Human Proteinase 3/PRTN3 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Ala26-Arg249) of Human PRTN3 fused with a polyhistidine tag at the C-terminus. Names Myeloblastin, AGP7, C-ANCA Antigen, Leukocyte Proteinase 3, PR-3, PR3, Neutrophil Proteinase 4, NP-4, P29, Wegener Autoantigen, PRTN3, MBN Accession # P24158 Formulation Supplied as a 0.2 μm filtered solution of 10mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence AEIVGGHEAQPHSRPYMASLQMRGNPGSHFCGGTLIHPSFVLTAAHCLRDIPQRLVNVVLGAHNV RTQEPTQQHFSVAQVFLNNYDAENKLNDVLLIQLSSPANLSASVATVQLPQQDQPVPHGTQCLAM GWGRVGAHDPPAQVLQELNVTVVTFFCRPHNICTFVPRRKAGICFGDSGGPLICDGIIQGIDSFV IWGCATRLFPDFFTRVALYVDWIRSTLRRVDHHHHHHBackground Proteinase-3 is a neutral serine proteinase that belongs to the peptidase S1 family and Elastase subfamily. It contains one peptidase S1 domain and it is expressed mainly in neutrophil granulocytes. The primary function of Proteinase-3 is thought to be degradation of extracellular proteins at sites of inflammation, but excessive or prolonged proteolytic activity may cause harmful effects in the body. It is the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.