产品中心
-
产品货号
产品名称
规格
销售价
会员价
货期
产地
订购
-
C256
Recombinant Human Ribonuclease UK114/p14.5
10ug
640
576
现货
国产
-
C256
Recombinant Human Ribonuclease UK114/p14.5
50ug
1752
1576.8
现货
国产
-
C256
Recombinant Human Ribonuclease UK114/p14.5
500ug
12320
11088
现货
国产
-
C256
Recombinant Human Ribonuclease UK114/p14.5
1mg
17600
15840
现货
国产
- 产品简介
- 使用说明
- 相关产品
- 参考文献
- 购买咨询
Catalog# C256 Source E.coli Description Recombinant Human Heat-Responsive Protein 12/HRSP12 is produced by our E. coli expression system. The target protein is expressed with sequence (Met1-Leu137) of Human HRSP12 fused with a His tag at the N-terminus. Names Ribonuclease UK114, 14.5 kDa Translational Inhibitor Protein, p14.5, Heat-Responsive Protein 12, UK114 Antigen Homolog, HRSP12, PSP Accession # P52758 Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, 10% Glycerol, pH 8.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence MGSSHHHHHHSSGLVPRGSHMSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQ LVSGGVAEEAKQALKNMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAY QVAALPKGSRIEIEAVAIQGPLTTASLBackground Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines compared with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.