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C535
Recombinant Human Serpin A5/Protein C Inhibitor
10ug
1200
1080
现货
国产
-
C535
Recombinant Human Serpin A5/Protein C Inhibitor
50ug
3520
3168
现货
国产
-
C535
Recombinant Human Serpin A5/Protein C Inhibitor
500ug
12320
11088
现货
国产
-
C535
Recombinant Human Serpin A5/Protein C Inhibitor
1mg
17600
15840
现货
国产
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Catalog# C535 Source HEK293 Description Recombinant Human Serpin A5 produced by transfected human cells is a secreted protein with sequence (His20-Pro406) of Human SERPINA5 fused with a polyhistidine tag at the C-terminus. Names Plasma Serine Protease Inhibitor, Acrosomal Serine Protease Inhibitor, Plasminogen Activator Inhibitor 3, PAI-3, PAI3, Protein C Inhibitor, PCI, Serpin A5, SERPINA5, PCI, PLANH3, PROCI Accession # P05154 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, pH 5.5 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence HRHHPREMKKRVEDLHVGATVAPSSRRDFTFDLYRALASAAPSQNIFFSPVSISMSLAMLSLGAG SSTKMQILEGLGLNLQKSSEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAM KTLYLADTFPTNFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFN HKGTQEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQQVE NGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLSGISNHSNIQV SEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFIVDNNILFLGKVNRPVDH HHHHHBackground Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.