| Catalog# |
CF94 |
| Source |
E.coli |
| Description |
Recombinant Human Serpin B5/SERPINB5 is produced with our E. coli expression system. The target protein is expressed with sequence (Met1-Ser231) of Human SERPINB5. |
| Names |
Serpin B5, Maspin, Peptidase Inhibitor 5, PI-5, SERPINB5, PI5 |
| Accession # |
P36952-2 |
| Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 |
| Shipping |
The product is shipped at ambient temperature. |
| Reconstitution |
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Storage |
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
| Purity |
Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. |
| Endotoxin |
Less than 0.1 ng/μg (1 IEU/μg). |
| Amino Acid Sequence |
MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKD VPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKG QINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFPESETKECPFRVNKVCGAAC SSKRSPIIDVKNDRDRVGHKSIPMRNLRARPAKCLS
|
| Background |
Serpin B5 is a secretive protein that belongs to the Serpin (Serine Protease Inhibitor) family and Ov-serpin subfamily. Serpin B5 is expressed in the prostate, testis, intestine, tongue, lung, and thymus. Serpin B5 exhibits no serine protease inhibitory activity. Serpin B5 also functions as tumor suppressor an angiogenesis inhibitor. It has been shown that Serpin B5 blocks the growth, invasion, and metastatic properties of mammary tumors. Furthermore, high expression of Serpin B5 is linked to squamous cell carcinoma in non-small-cell lung cancer. |
