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C385
Recombinant Human CD172a/SIRPA/Signal-Regulatory Protein α
10ug
560
504
现货
国产
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C385
Recombinant Human CD172a/SIRPA/Signal-Regulatory Protein α
50ug
1680
1512
现货
国产
-
C385
Recombinant Human CD172a/SIRPA/Signal-Regulatory Protein α
500ug
12320
11088
现货
国产
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C385
Recombinant Human CD172a/SIRPA/Signal-Regulatory Protein α
1mg
17600
15840
现货
国产
-
C385
Recombinant Human SIRPA/Signal-Regulatory Protein α/CD172a
10ug
560
504
现货
国产
-
C385
Recombinant Human SIRPA/Signal-Regulatory Protein α/CD172a
50ug
1680
1512
现货
国产
-
C385
Recombinant Human SIRPA/Signal-Regulatory Protein α/CD172a
500ug
12320
11088
现货
国产
-
C385
Recombinant Human SIRPA/Signal-Regulatory Protein α/CD172a
1mg
17600
15840
现货
国产
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Catalog# C385 Source HEK293 Description Recombinant Human Signal-Regulatory Protein α-1 is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (Glu31 Arg370) of Human SIRPA fused with a polyhistidine tag at the C-terminus. Names Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1, SHP Substrate 1, SHPS-1, Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs, Bit, CD172 Antigen-Like Family Member A, Inhibitory Feceptor SHPS-1, Macrophage Fusion Receptor, MyD-1 Antig Accession # P78324 Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence EEELQVIQPDKSVSVAAGESAILHCTVTSLIPVGPIQWFRGAGPARELIYNQKEGHFPRVTTVSE STKRENMDFSISISNITPADAGTYYCVKFRKGSPDTEFKSGAGTELSVRAKPSAPVVSGPAARAT PQHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKVVLTREDVHSQV ICEVAHVTLQGDPLRGTANLSETIRVPPTLEVTQQPVRAENQVNVTCQVRKFYPQRLQLTWLENG NVSRTETASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQ GSNTAAENTGSNERNVDHHHHHHBackground Signal Regulatory Protein α (SIRPα) is a monomeric approximately 90 kD type I transmembrane glycoprotein. The 504 amino acid human SIRPα contains two Ig-like C1-type domains and one Ig-like V-type domain. SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation