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CD61
Recombinant Human SMPDL3A/ASM-like phosphodiesterase 3a
10ug
1200
1080
现货
国产
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CD61
Recombinant Human SMPDL3A/ASM-like phosphodiesterase 3a
50ug
3520
3168
现货
国产
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CD61
Recombinant Human SMPDL3A/ASM-like phosphodiesterase 3a
500ug
17080
15372
现货
国产
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CD61
Recombinant Human SMPDL3A/ASM-like phosphodiesterase 3a
1mg
24400
21960
现货
国产
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Catalog# CD61 Source Human Cells Description Recombinant Human Acid sphingomyelinase-like phosphodiesterase 3a/SMPDL3A is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Leu23-Tyr453) of Human SMPDL3A fused with a polyhistidine tag at the C-terminus. Names Acid sphingomyelinase-like phosphodiesterase 3a, ASM-like phosphodiesterase 3a,SMPDL3A,ASML3A Accession # Q92484 Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 Shipping The product is shipped at ambient temperature. Reconstitution Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in 1X PBS.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/µg (1 IEU/µg). Amino Acid Sequence LPVAPAGGRNPPPAIGQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVLCDSPYQL ILSAFDFIKNSGQEASFMIWTGDSPPHVPVPELSTDTVINVITNMTTTIQSLFPNLQVFPALGNH DYWPQDQLPVVTSKVYNAVANLWKPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPN IMTLNKTDPANQFEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQNITAMREYYNEKLIDIFQKY SDVIAGQFYGHTHRDSIMVLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKL LDMLQYYLNLTEANLKGESIWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFV SYDSSVTCDKTCKAFQICAIMNLDNISYADCLKQLYIKHNYVDHHHHHHBackground Acid sphingomyelinase-like phosphodiesterase 3a (SMPDL3A ) is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases.