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C543
Recombinant Human SPINK4/Serine protease inhibitor Kazal-type
10ug
840
756
现货
国产
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C543
Recombinant Human SPINK4/Serine protease inhibitor Kazal-type
50ug
2520
2268
现货
国产
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C543
Recombinant Human SPINK4/Serine protease inhibitor Kazal-type
500ug
12320
11088
现货
国产
-
C543
Recombinant Human SPINK4/Serine protease inhibitor Kazal-type
1mg
17600
15840
现货
国产
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Catalog# C543 Source HEK293 Description Recombinant Human Serine Protease Inhibitor Kazal-Type 4/SPINK4 produced by transfected human cells is a secreted protein with sequence (Gly27-Cys86) of human SPINK4 fused with a polyhistidine tag at the C-terminus. Names Serine Protease Inhibitor Kazal-Type 4, Peptide PEC-60 Homolog, SPINK4 Accession # O60575 Formulation Supplied as a 0.2 μm filtered solution of 20mM MES, 150mM NaCl, 2mM CaCl2, 1mM DTT, 0.05% Brij35, 10% Glycerol, pH 6.0 Shipping The product is shipped on dry ice/ice packs. Storage Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.Purity Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin Less than 0.1 ng/μg (1 IEU/μg). Amino Acid Sequence GKLPFSRMPICEHMVESPTCSQMSNLVCGTDGLTYTNECQLCLARIKTKQDIQIMKDGKCVDHHH HHHBackground Serine Protease Inhibitor Kazal-Type 4 (SPINK4) is a secreted protein containing one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.